Anti-Cytokeratin/Keratin K5/K8 Pan Epithelial Ker Monoclonal Antibody
| Product Name | Anti-Cytokeratin/Keratin K5/K8 Pan Epithelial Ker Monoclonal Antibody |
|---|---|
| Description | Cytokeratins are proteins of keratin-containing intermediate filaments found in the intracytoplasmic cytoskeleton of epithelial tissue. Keratin, type II cytoskeletal 5 also known as KRT5 is a protein that in human is encoded by the KRT5 gene. Keratin, type I cytoskeletal 8 also known as cytokeratin-8 (CK-8) or keratin-8 (K8) is a keratin protein that in human is encoded by the KRT8 gene. C 22 represents an excellent marker for distinguishing carcinomas from all non-epithelial tumors. |
| Synonyms | K5, CK5, DDD, DDD1, EBS2, KRT5A, K8, KO, CK8, CK-8, CYK8, K2C8, CARD2 |
| Clone | Ks 5+8.22/C 22 |
| Immunogen | Human cytokeratin/Keratin K8, purified from cultured human HCF-7 cells by SDS-PAGE |
| Isotype | IgG1 |
| Specificity | The antibody specifically reacts with keratins K5 and K8 present in nearly all epithelia. Polypeptide reacting:Mr 52 500, Mr 58 000 keratins (type II keratins K5 and K8; formerly also designated cytokeratins 5 and 8) of human epithelial cells. Epitope has been mapped to aa 353-367 on alpha helical rod domain (see Waseem et al., 2004) |
| Reactivity | Amphibian, Bovine, Human, Mouse, Porcine |
| Applications | WB |
| Form | Purified (Protein A), in PBS containing 1% BSA and 0.1% sodium-azide |
| Storage | 2-8C for immediate use, or at -20C (aliquot) |
| References | Bartek, J. et al. (1991) J. Pathol. 164: 215-224Moll, R.et al. (1982) Cell 31: 11-24Waseem A et al. (2004) Biochemistry 43: 1283-1295 |
| Supplier | ARP |
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