| Product Name | Anti-Cytokeratin/Keratin K6 Polyclonal Antibody |
|---|---|
| Description | Cytokeratins/Keratins are precisely regulated in tissue and little is known about the molecular mechanisms underlying this regulation. However, the expression pattern of cytokeratin 6 is known to be particularly complex. It is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyperproliferative situations. |
| Synonyms | K6, Krt2-6, Krt-2.6 |
| Immunogen | Synthetic peptide of human keratin K6 (formerly alsodesignated cytokeratin 6; MAS TST TIR SHS S-C), coupled toKLH |
| Specificity | MW 56,000 (pI 7.8) intermediate filament polypeptide, keratin K6, detected by immunohistochemistry in non-keratinized squamous epithelia and proliferating cells of epidermis (e.g. within psoriatic lesions). The antibody is completely negative on non-stratified epithelia. Suitable for discrimination of keratinizing and non-keratinizing squamous cell carcinoma versus e.g. poorly differentiated adenocarcinoma. |
| Reactivity | Human, Mouse |
| Applications | IF, IHC |
| Form | Stabilized Serum |
| Storage | 2-8C |
| References | Langbein L et al. (2006) J Invest Dermatol 126: 2377-2386 |
| Supplier | ARP |
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