Anti-Cytokeratin/Keratin K6 Monoclonal Antibody

Category: Antibodies
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03-61090
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Product Name Anti-Cytokeratin/Keratin K6 Monoclonal Antibody
Description Cytokeratins are precisely regulated in tissue and little is known about the molecular mechanisms underlying this regulation. However, the expression pattern of cytokeratin 6 is known to be particularly complex. It is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyperproliferative situations. Mouse Monoclonal Antibody to Cytokeratin/Keratin K6. The antibody is suitable for discrimination of keratinizing and non-keratinizing squamous cell carcinoma versus e.g. poorly differentiated adenocarcinoma. Polypeptide reacting: Mr 56 000 polypeptide (keratin K6; formerly also designated cytokeratin 6) of human squamous epithelia.
Synonyms K6, Krt2-6, Krt-2.6
Clone Ks6.KA12
Immunogen Keratin K6 of human callus cytoskeletal preparation
Isotype IgG1
Specificity Ks6.KA12 represents an excellent marker fornonkeratinized squamous epithelia and proliferating cells of epidermis (e.g. within proriatic lesions)
Reactivity Human, Mouse
Applications IHC, WB
Form Purified (Protein A), in PBS containing 1% BSA and 0.1% sodium-azide
Storage 2-8C for immediate use, or at -20C (aliquot)
References Smedts, F. et al. (1992) Am. J. Pathol. 141: 497-511Wetzels RHW, et al. (1991) Am. J. Pathol. 138: 751-763Demirkesen, C. et al. (1995) J. Cutan. Pathol. 22: 518-535Moll, R. (1995). In: Aktuelle Aspekte der Tumorimmunologie in der Gynaekologie. W. Zuckschwerdt VerlagHerrmann, T. et al. (2003) J. Cell Biol. 161: 1105-1115
Supplier ARP

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