| Product Name | Anti-Cytokeratin/Keratin K8 Monoclonal Antibody |
|---|---|
| Description | This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. Ks 8.7 represents an excellent marker to discriminate simple epithelia from those of different origin. Polypeptide Reacting: Mr 52 500 polypeptide (keratin K8; formerly also designated cytokeratin 8) of human epithelia. |
| Synonyms | K8, KO, CK8, CK-8, CYK8, K2C8, CARD2 |
| Clone | Ks 8.7 |
| Immunogen | Cytoskeletal proteins from cultured HeLa cells |
| Isotype | IgG1 |
| Specificity | Tumors Specifically Detected: All adeno-CA tested; undifferentiated CA; cervix CA; hepatocellular CA |
| Reactivity | Hamster, Human, Mouse, Opossum, Rat, Mammal |
| Applications | WB |
| Form | Purified (Protein A), in PBS containing 1% BSA and 0.1% sodium-azide |
| Storage | 2-8C for immediate use, or at -20C (aliquot) |
| References | Bartek, J. et al (1991) J. Pathol. 164: 215-224Heid, H. et al (1991) Differentiation submittedMoll, R. et al. (1982) Cell 31: 11-24Osborn, M.et al. (1986) Lab. Investigation 55(4): 497-504Gomi, H. et al. (1995) neuron 14: 29-41Stumptner, C. et al. (2002) Hepatology 35: 1053-1062 |
| Supplier | ARP |
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