| Product Name | Anti-Desmocollin 1 Monoclonal Antibody |
|---|---|
| Description | The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms. Mouse Monoclonal Antibody to Desmocollin 1. Mab localizes Dsc1 present in suprabasal layers of interfollicular epidermis, specific cell layers (e.g. in hair follicle root sheath), and Hassall bodies (spheroidal formations of densely packed reticulum-derived cells in the thymus). |
| Synonyms | CDHF1, DG2/DG3 |
| Clone | Dsc1-U100 |
| Immunogen | Synthetic peptide corresponding to sequence present within the intracellular part of human desmocollin 1 (HQTLESVKGVGQGDTGRYATDWQC) |
| Isotype | IgG1 |
| Specificity | Reacts with 111 kD (form a") and 103 kD (form "b") polypeptides (desmo- collin 1 splice forms, both at pI 5.2) from human epidermal desmosomes. Positive on primary keratinocytes, however, restricted to local piles of differentiated cells. All simple epithelia are negative. |
| Reactivity | Human |
| Applications | IHC |
| Form | Purified (Protein A), in PBS containing 1% BSA and 0.1% sodium-azide |
| Storage | 2-8C for immediate use, or at -20C (aliquot) |
| References | 1. Nuber, U.A., et al. (1996) Eur. J. Cell Biol. 66: 69-74 2. SchÌÄå_fer, S. & Franke, W.W. (1996) Differentiation 60: 99-108 3. Moll I et al. (1999) Arch Dermatol Res 291: 437-446 4. Kurzen H et al. (1998) Differentiation 63: 295-304 5. Akat K et al. (2003) Acta Neuropathol 106: 337-347 |
| Supplier | ARP |
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