| Product Name | Anti-Glucagon Polyclonal Antibody |
|---|---|
| Description | The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. |
| Synonyms | GCG, GLP1, GLP2, GRPP |
| Immunogen | Highly purified porcine pancreatic glucagon (Novo) |
| Specificity | The glucagons antibody can be used for the detection of pancreatic endocrine tumors. The antigen localization is cytoplasmic. Absorption with 10-100 ?l glucagon per ml diluted antiserum abolishes staining. |
| Reactivity | Human, Porcine, Rat |
| Applications | IF, IHC |
| Form | Serum containing 0.1% sodium azide |
| Storage | 2-8C for immediate use, or at -20C (aliquot) |
| References | Myrsen-Axcrona U et al. (1997) Regulary Peptides 68: 165-175 |
| Supplier | ARP |
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