Anti-Nephrin Antibody Polyclonal Antibody

Category: Antibodies
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03-GP-N2
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Product Name Anti-Nephrin Antibody Polyclonal Antibody
Description This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.
Synonyms CNF, NPHN, nephrin
Immunogen Synthetic peptide (intracellular domain, aa1243-1256)
Specificity The antibody reacts specifically with nephrin, first described as a kidney podocyte marker protein (MW 135,000 calculated from aa sequence data; apparent Mr 185,000 after SDS-PAGE). The antibody stains positively podocytes of the kidney, radial glial cells of the brain, Sertoli cells of testis, and beta islet cells of the pancreas.
Reactivity Human, Mouse
Applications IHC, WB
Form Stabilized Serum
Storage 2-8C
References Kestila M. et al. (1998) Mol Cell. 4: 575-582 Ruotsalainen V. et al. (1999) Proc Natl Acad Sci USA. 96: 7962-7967 Holthofer H. et al. (1999) Am J Pathol 155: 1681-1687 Putaala H. et al. (2001) Hum Mol Genet 10: 1-8 Huh W, Kim et al. (2002) Nephrol Dial Transplant 17: 478-484 Aaltonen P. et al. (2001) Lab Invest 81: 1185-1190 Bussolati B. et al. (2005) J Am Soc Nephrol 16: 1936-1947
Supplier ARP

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