Aurora kinase A, 1-403aa, Human, Recombinant

Catalog
01-2098A
$0.00
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Proteins, Recombinant
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Product Name Aurora kinase A, 1-403aa, Human, Recombinant
Background Aurora Kinase A is a member of a family of mitotic serine/threonine kinases. It is implicated with important processes during mitosis and meiosis whose proper function is integral for healthy cell proliferation. Aurora kinase A is highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also this protein plays a crucial role in tumourigenesis and is overexpressed in many kinds of cancers. Recombinant human Aurora-A fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Synonyms Serine/threonine-protein kinase 6, Aurora-A, AIK, ARK1, AURA, BTAK, STK15, STK6, Aurora kinase A, AURKA, Serine/threonine-protein kinase 6 Aurora 2, Aurora A, aurora kinase A, IAK, Serine/threonine kinase 15.
Species Human
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MDRSKENCIS GPVKATAPVG GPKRVLVTQQ FPCQNPLPVN SGQAQRVLCP SNSSQRIPLQ AQKLVSSHKP VQNQKQKQLQ ATSVPHPVSR PLNNTQKSKQ PLPSAPENNP EEELASKQKN EESKKRQWAL EDFEIGRPLG KGKFGNVYLA REKQSKFILA LKVLFKAQLE KAGVEHQLRR EVEIQSHLRH PNILRLYGYF HDATRVYLIL EYAPLGTVYR ELQKLSKFDE QRTATYITEL ANALSYCHSK RVIHRDIKPE NLLLGSAGEL KIADFGWSVH APSSRRTTLC GTLDYLPPEM IEGRMHDEKV DLWSLGVLCY EFLVGKPPFE ANTYQETYKR ISRVEFTFPD FVTEGARDLI SRLLKHNPSQ RPMLREVLEH PWITANSSKP SNCQNKESAS KQS
Molecular Weight 41.6 kDa (367aa), confirmed by MALDI-TOF.
Concentration 1 mg/ml (determined by Bradford assay)
Form Liquid, in 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol 1mM DTT.
Purity > 95% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_003591
Host E.coli
Tag His-tag
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Tchatchou S., et al. (2007). Cancer lett. 247(2): 266-72
Chen SS., et al. (2002). EMBO J. 21(17): 4491-9

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