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|Product Name||BHMT2, 1-363aa, Human|
|Background||BHMT2 is involved in the regulation of homocysteine metabolism. Homocysteine is a sulfur-containing amino acid that plays a crucial role in methylation reactions. Transfer of the methyl group from betaine to homocysteine creates methionine, which donates the methyl group to methylate DNA, proteins, lipids, and other intracellular metabolites. BHMT2 is one of two methyl transferases that can catalyze the transfer of the methyl group from betaine to homocysteine. Recombinant human BHMT2 protein, fused to His-tag at N-terminus, was expressed in E.coli.|
|Synonyms||S-methylmethionine-homocysteine S-methyltransferase BHMT2 isoform 1, betaine--homocysteine S-methyltransferase 2|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MGSMAPAGRP GAKKGILERL ESGEVVIGDG SFLITLEKRG YVKAGLWTPE AVIEHPDAVR QLHMEFLRAG
SNVMQTFTFS ASEDNMESKW EDVNAAACDL AREVAGKGDA LVAGGICQTS IYKYQKDEAR IKKLFRQQLE VFAWKNVDFL IAEYFEHVEE
AVWAVEVLKE SDRPVAVTMC IGPEGDMHDI TPGECAVRLV KAGASIVGVN CRFGPDTSLK TMELMKEGLE WAGLKAHLMV QPLGFHAPDC
GKEGFVDLPE YPFGLESRVA TRWDIQKYAR EAYNLGVRYI GGCCGFEPYH IRAIAEELAP ERGFLPPASE KHGSWGSGLD MHTKPWIRAR
ARREYWENLL PASGRPFCPS LSKPDF
|Molecular Weight||32.6 kDa (295aa)|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol|
|Purity||> 90% by SDS-PAGE|
|NCBI Accession #||NP_060084|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Li F., et al. (2008) Mol Genet Metab. 94(3): 326-35.
Mostowaka A., et al. (2010) Eur Oral Sci. 118(4): 325-32.
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