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|Product Name||BID, 1-195aa, Human, Recombinant|
|Background||BID is a pro-apoptotic Bcl-2 protein containing only the BH3 domain. In response to apoptotic signaling, BID interacts with another Bcl-2 family protein, Bax, leading to the insertion of Bax into the outer mitochondrial membrane. Bax is believed to induce the opening of the mitochondrial voltage-dependent anion channel. This results in the release of cytochrome c and other pro-apoptotic factors from the mitochondria leading to activation of caspases. Recombinant BID protein was expressed in E.coli and purified by using conventional chromatography techniques.|
|Synonyms||FP497, MGC15319, MGC42355, BH3 interacting domain death agonist isoform 2, BID, BH3 interacting domain death agonist isoform 2 Apoptotic death agonist, Apoptotic death agonist BID, BH3 interacting domain death agonist, HGNC:1050, BH3 interacting domain death agonist p11, BH3 interacting domain death agonist p13, BH3 interacting domain death agonist p15, BID isoform ES(1b), BID isoform L(2), Desmocollin type 4, Human BID coding sequence, OTTHUMP00000196197, p11 BID, p13 BID, p15 BID, p22 BID.|
|Amino Acid Sequence||MDCEVNNGSS LRDECITNLL VFGFLQSCSD NSFRRELDAL GHELPVLAPQ WEGYDELQTD GNRSSHSRLG RIEADSESQE DIIRNIARHL AQVGDSMDRS IPPGLVNGLA LQLRNTSRSE EDRNRDLATA LEQLLQAYPR DMEKEKTMLV LALLLAKKVA SHTPSLLRDV FHTTVNFINQ NLRTYVRSLA RNGMD|
|Molecular Weight||64.8 kDa (563aa)|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol|
|Purity||> 95% by SDS-PAGE|
|NCBI Accession #||NP_001187|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Luo, X., et al. (1998). Cell. 94:481
Li, H., et al. (1998). Cell. 94:491
Zha, J., et al. (2000). Science 290:1761
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