BLyS, 134-285aa Human, Recombinant

Proteins, Recombinant
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Product Name BLyS, 134-285aa Human, Recombinant
Background B lymphocyte stimulator(BLyS),a member of the tumor necrosis factor (TNF) superfamily of cytokines, induces B-cell proliferation and immunoglobulin secretion and is a key regulator of peripheral B-cell populations in vivo.. BLyS is made by immune-cells called monocytes and macrophages. When monocytes and macrophages are activated, BLyS is released and binds to a receptor found only on B cells. Recombinant human BLyS, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Synonyms B-cell activating factor, BAFF, CD257, TALL1, THANK, ZTNF4, TNFSF13B, TNFSF20, BlyS, B lymphocyte stimulator, B lymphocyte stimulator
Species Human
Molecular Weight 49.2 kDa (443 aa), confirmed by MALDI-TOF.
Concentration 1 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris pH7.5, 20% glycerol.
Purity > 95% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_006564
Host E.coli
Tag His-tag
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Allan SM., et al. (2005), Nat. Rev. Immunol. 5:629.
Michaud DS., et al. (2006), Cancer Res. 66(8):4525-30

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