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|Product Name||CA3, 1-260aa, Human|
|Background||CA3, also known as carbonic anhydrase III, is an enzyme that catalyses rapid conversion of carbon dioxide to bicarbonate and protons (CO2 + H2O = HCO3 + H+). This protein is involved in a variety of biological processes, including respiration, calcifica-tion, acid-base balance, bone resorption and the formation of aqueous humor, cerebrospinal fluid, saliva and gastric juice. It contains a zinc ion in their active site and the primary function of this enzyme is known to maintain acid-base balance in blood and other tissues, and to help transport carbon dioxide of tissues. Recombinant CA3 protein was expressed in E.coli and purified by using conventional chromatography techniques.|
|Synonyms||CAIII, Car3, Carbonic anhydrase III, CA3,|
|Amino Acid Sequence||MAKEWGYASH NGPDHWHELF PNAKGENQSP IELHTKDIRH DPSLQPWSVS YDGGSAKTIL NNGKTCRVVF DDTYDRSMLR GGPLPGPYRL RQFHLHWGSS DDHGSEHTVD GVKYAAELHL VHWNPKYNTF KEALKQRDGI AVIGIFLKIG HENGEFQIFL DALDKIKTKG KEAPFTKFDP SCLFPACRDY WTYQGSFTTP PCEECIVWLL LKEPMTVSSD QMAKLRSLLS SAENEPPVPL VSNWRPPQPI NNRVVRASFK|
|Molecular Weight||61.6 kDa (547aa)|
|Concentration||0.5 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 0.1M NaCl|
|Purity||> 90% by SDS-PAGE|
|NCBI Accession #||AAH04897|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Lindskog S., et al (1997) Pharmacol Ther, 74(1):1-20.
Sawaya MR., et al (2006) J Biol Chem. 281(11):7546-55
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