Calsequestrin-2, 20-399aa, Human

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01-1799-2
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Proteins, Recombinant
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Product Name Calsequestrin-2, 20-399aa, Human
Background Calsequestrin2 is a calcium-binding protein of the sarcoplasmic reticulum. The protein helps hold calcium in the cisterna of the sarcoplasmic reticulum after a muscle contraction, even though the concentration of calcium in the sarcoplasmic reticulum is much higher than in the cytosol. It also helps sarcoplasmic reticulum store an amazing amount of calcium ions. Recombinant Calsequestrin2 protein was expressed in E.coli and purified by using conventional chromatography techniques.
Synonyms PDIB2, CASQ2, Calsequestrin 2 (cardiac muscle), Calsequestrin 2 fast twitch cardiac muscle, Calsequestrin cardiac muscle isoform, Calsequestrin fast twitch cardiac muscle, Calsequestrin2, Cardiac calsequestrin 2, CASQ 2, ESTM52, FLJ26321, FLJ93514, PDIB2.
Species Human
Amino Acid Sequence MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMEEG LNFPTYDGKD RVVSLSEKNF KQVLKKYDLL CLYYHEPVSS DKVTQKQFQL KEIVLELVAQ VLEHKAIGFV MVDAKKEAKL AKKLGFDEEG SLYILKGDRT IEFDGEFAAD VLVEFLLDLI EDPVEIISSK LEVQAFERIE DYIKLIGFFK SEDSEYYKAF EEAAEHFQPY IKFFATFDKG VAKKLSLKMN EVDFYEPFMD EPIAIPNKPY TEEELVEFVK EHQRPTLRRL RPEEMFETWE DDLNGIHIVA FAEKSDPDGY EFLEILKQVA RDNTDNPDLS ILWIDPDDFP LLVAYWEKTF KIDLFRPQIG VVNVTDADSV WMEIPDDDDL PTAEELEDWI EDVLSGKINT EDDDEDDDDD DNSDEEDNDD SDDDDDE
Molecular Weight 55.7 kDa (515aa)
Concentration 0.5 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol
Purity > 95% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_001223
Host E.coli
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Wang S,, et al. (1998) Nat. Struct. Biol.. 5(6):476-83.
Lahat H, et al. (2001) Am J Hum Genet. 69(6):1378-84.

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