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|Product Name||Carbonyl reductase 3, 1-277aa, Human, Recombinant|
|Background||Carbonyl reductase 3(CBR3) is one of several monomeric NADPH-dependent oxidoreductases. This protein catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. It also contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. Some studies suggest that it mediates 9-cis-retinoic acid-induced cytostatis and is a potential prognostic marker for oral malignancy. Recombinant human CBR3, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.|
|Synonyms||Carbonyl reductase 3, CBR3, NADPH-dependent carbonyl reductase, Carbonyl reductase (NADPH) 3, EC 188.8.131.52, hCBR3, Carbonyl reductase (NADPH) 3 EC 184.108.40.206, NADPH dependent carbonyl reductase 3, SDR21C2, Short chain dehydrogenase/reductase family 21C member 2.|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MSSCSRVALV TGANRGIGLA IARELCRQFS GDVVLTARDV ARGQAAVQQL QAEGLSPRFH QLDIDDLQSI RALRDFLRKE YGGLNVLVNN AAVAFKSDDP MPFDIKAEMT LKTNFFATRN MCNELLPIMK PHGRVVNISS LQCLRAFENC SEDLQERFHS ETLTEGDLVD LMKKFVEDTK NEVHEREGWP NSPYGVSKLG VTVLSRILAR RLDEKRKADR ILVNACCPGP VKTDMDGKDS IRTVEEGAET PVYLALLPPD ATEPQGQLVH DKVVQNW|
|Molecular Weight||19.7 kDa (173 aa), confirmed by MALDI-TOF.|
|Concentration||0.5 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH8.0) containing 0.1M NaCl, 30% glycerol, 1mM DTT.|
|Purity||> 95% by SDS-PAGE|
|NCBI Accession #||NP_001227|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Ohkura-Hada S., et al. (2008). Open Dent J. 2:78-88.
Miura T., et al. (2009). Life Sci. 85(7-8):303-8.
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