CD8B, 22-170aa, Human

Catalog
01-P2520
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Proteins, Recombinant
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Product Name CD8B, 22-170aa, Human
Background CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Recombinant human CD8B protein, fused to His-tag at N-terminus, was expressed in E.coli.
Synonyms T-cell surface glycoprotein CD8 beta chain isoform 5 precursor, CD8B1, LEU2, LY3, LYT3, P37
Species Human
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MGSLQQTPAY IKVQTNKMVM LSCEAKISLS NMRIYWLRQR QAPSSDSHHE FLALWDSAKG TIHGEEVEQE KIAVFRDASR FILNLTSVKP EDSGIYFCMI VGSPELTFGK GTQLSVVDFL PTTAQPTKKS TLKKRVCRLP RPETQKGPLC SP
Molecular Weight 10.8 kDa (101aa), confirmed by MALDI-TOF
(Molecular size on SDS-PAGE will appear higher)
Concentration 0.5 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 50% glycerol.
Purity > 80% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_004922
Host E.coli
Tag His-tag
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Heigele,A, et al. (2012) J. Virol. 86 (1), 36-48
Laugel,B., et al. (2011) J. Leukoc. Biol. 90 (6), 1089-1099

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