CEBP-alpha, (bZIPregion, residues 270-358, Human)

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01-2224A
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Proteins, Recombinant
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Product Name CEBP-alpha, (bZIPregion, residues 270-358, Human)
Background CCAAT/enhancer binding protein(C/EBP) alpha is a family of transcription factors that all contain a highly conserved, basic-leucine zipper domain at the C-terminus that is involved in dimerization and DNA binding. C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP family consist of several related proteins, C/EBP alpha, beta, gamma,delta, that form homodimers and that form heterodimers with each other. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein; a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. C/EBPs differ significantly in their physiological functions and in their downstream target genes. For example, mice lacking C/EBP alpha die shortly after birth due to severe hypoglycemia and the absence of glycogen storage in liver, whereas knockout of C/EBPbeta causes defects in female reproduction The bZip region of CEBP-alpha (residues 270-358)was produced in E.coli and purified by ion-exchange chromatography and FPLC gel-filtration chromatography.
Synonyms CEBPA, CEBP-alpha bZIPregion residues 270-358, C/EBP alpha, CCAAT/enhancer-binding protein alpha, CAAT/enhancer binding protein a, Apoptotic cysteine protease, Apoptotic protease Mch 5, CAP4, Caspase 8 precursor, CCAAT Enhancer Binding Protein alpha, CEBP, CEBP A, CEBP alpha, FADD homologous ICE/CED 3 like protease, FADD like ICE, FLICE, ICE8, MACH, MCH5, MORT1 associated CED 3 homolog
Species Human
Amino Acid Sequence MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMGAG KAKKSVDKNS NEYRVRRERN NIAVRKSRDK AKQRNVETQQ KVLELTSDND RLRKRVEQLS RELDTLRGIF RQLPESSLVK AMGNCA
Molecular Weight 16.8 kDa (148 aa), confirmed by MALDI-TOF.
Concentration 0.5 mg/ml (determined by Bradford assay)
Form Liquid, in 10mM Sodium Citrate buffer (pH 3.5) containing 10% glycerol
Purity > 95% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_004355
Host E.coli
Tag His-tag
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Subramanian,L., et.al.(2003) J.Biol.Chem. 278(11) 9134 - 9141
Gombart,A.F., et al (2002) Blood 99(4) 1332-1340

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