CGB, 21-165aa, Human

Catalog
01-P2030
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Proteins, Recombinant
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Product Name CGB, 21-165aa, Human
Background CGB is a member of the glycoprotein hormone beta chain family and is the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. Recombinant human CGB protein, fused to His-tag at N-terminus, was expressed in E.coli.
Synonyms Choriogonadotropin subunit beta precursor, CGB3, CGB5, CGB7, CGB8, Hcgb
Species Human
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MGSSKEPLRP RCRPINATLA VEKEGCPVCI TVNTTICAGY CPTMTRVLQG VLPALPQVVC NYRDVRFESI RLPGCPRGVN PVVSYAVALS CQCALCRRST TDCGGPKDHP LTCDDPRFQD SSSSKAPPPS LPSPSRLPGP SDTPILPQ
Molecular Weight 27.8 kDa (243aa)
Concentration 1 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M UREA, 10% glycerol
Purity > 85% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_000728
Host E.coli
Tag His-tag
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Andrusiewicz M, Szczerba A, et al. (2011). J Transl Med. 9:130.
Gregor CR, Cerasoli E, et al. (2011). J Biol Chem. 286(28):25016-26.

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