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|Product Name||CIB1, 1-191aa, Human, Recombinant|
|Background||CIB, KIP(Kinase interacting protein), SIP2-28 (SNK interacting protein2-28), CALMYRIN Description: CIB1 (Calcium and integrin binding 1) is regulatory protein with 50% homology to calmodulin and calcineurin B, that encodes a member of the calcium-binding protein family. The specific function of this protein has not yet been determined; however this protein is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end joining. Also CIB1 is widely expressed and binds to a number of effectors, such as integrin alpha IIb, PAK1, and polo-like kinases, in different tissues. Recombinant human CIB1, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Synonyms||Calcium and integrin binding 1, CIB, KIP (Kinase interacting protein), SIP2-28(SNK interacting protein2-28), CALMYRIN, CIB1, Calcium and integrin binding 1 Calcium and integrin binding 1 (calmyrin), Calcium and integrin binding protein 1, CIB, DNA PKcs interacting protein, Human Snk interacting protein 2 to 28 mRNA complete cds, Kinase interacting protein, PRKDCIP, SIP2 28, SNK interacting protein 2 to 28.|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MGGSGSRLSK ELLAEYQDLT FLTKQEILLA HRRFCELLPQ EQRTVESSLR AQVPFEQILS LPELKANPFK ERICRVFSTS PAKDSLSFED FLDLLSVFSD TATPDIKSHY AFRIFDFDDD GTLNREDLSR LVNCLTGEGE DTRLSASEMK QLIDNILEES DIDRDGTINL SEFQHVISRS PDFASSFKIV L|
|Molecular Weight||14.5kDa (126aa), confirmed by MALDI-TOF.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in. 20mM Tris-HCl pH7.5, 0.1M NaCl, 5mM beta-Mercaptoethanol.|
|Purity||> 95% by SDS-PAGE|
|NCBI Accession #||NP_006375|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Yuan W, et al, (2006). Mol Cell Biochem. 26(22): 8507
Yuan, et al, (2006). J Cell Biol. 172(2) :169-75
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