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|Product Name||Cofilin 1, 1-166aa, Human, Recombinant|
|Background||Cofilin is a family of actin-binding proteins which disassembles actin filaments. It is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus. Recombinant human Cofilin, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques|
|Synonyms||CFL1, CFL, Cofilin 1, CFL1, CFL, 18 kDa phosphoprotein(p18) 18 kDa phosphoprotein, CFL 1, Cofilin 1, Cofilin 1 non muscle, Cofilin non muscle isoform, P18.|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MASGVAVSDG VIKVFNDMKV RKSSTPEEVK KRKKAVLFCL SEDKKNIILE EGKEILVGDV GQTVDDPYAT FVKMLPDKDC RYALYDATYE TKESKKEDLV FIFWAPESAP LKSKMIYASS KDAIKKKLTG IKHELQANCY EEVKDRCTLA EKLGGSAVIS LEGKPL|
|Endotoxin Level||< 1.0 EU per 1 microgram of protein (determined by LAL method)|
|Molecular Weight||34.8 kDa (303 aa), confirmed by MALDI-TOF.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20 mM Tris-HCl buffer (pH 7.5) containing 5 mM DTT, 10% glycerol|
|Purity||> 95% by SDS-PAGE|
|NCBI Accession #||NP _005498|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Mannherz H.G., et al (2007). J. Mol. Biol. 366 (3)745-755.
Olsen J.V., et al (2006). Cell. 127(3)635-648
Yang N., et al (1998) Nature. 393(6687)809-812
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