| Product Name | CPEB1, 1-561aa, Human |
|---|---|
| Description | CPEB1 is a member of the cytoplasmic polyadenylation element (CPE) binding protein family. This highly conserved protein binds to a specific RNA sequence called the CPE found in the 3' UTR of some mRNAs. Similar proteins in Xenopus and mouse function to induce cytoplasmic polyadenylation of dormant mRNAs with short polyA tails, resulting in their translation. Members of this protein family regulate translation of cyclin B1 during embryonic cell divisions. Recombinant human CPEB1 protein, fused to His-tag at N-terminus, was expressed in E.coli. |
| Synonyms | Cytoplasmic polyadenylation element bindi ng protein 1, CEBP, CPE-BP1, CPEB |
| Host | E.coli |
| Molecular Weight | 53.1 kDa (468aa) |
| Amino Acid Sequence |
MGSSHHHHHH SSGLVPRGSH MGSMAFPLEE EAGRIKDCWD NQEAPALSTC SNANIFRRIN AILDNSLDFS RVCTTPINRG IHDHLPDFQD SEETVTSRML FPTSAQESSR GLPDANDLCL GLQSLSLTGW DRPWSTQDSD SSAQSSTHSV LSMLHNPLGN VLGKPPLSFL PLDPLGSDLV DKFPAPSVRG SRLDTRPILD SRSSSPSDSD TSGFSSGSDH LSDLISSLRI SPPLPFLSLS GGGPRDPLKM GVGSRMDQEQ AALAAVTPSP TSASKRWPGA SVWPSWDLLE APKDPFSIER EARLHRQAAA VNEATCTWSG QLPPRNYKNP IYSCKVFLGG VPWDITEAGL VNTFRVFGSL SVEWPGKDGK HPRCPPKGYV YLVFELEKSV RSLLQACSHD PLSPDGLSEY YFKMSSRRMR CKEVQVIPWV LADSNFVRSP SQRLDPSRTV FVGALHGMLN AEALAAILND LFGGVVYAGI DTDKHKYPIG SGRVTFNNQR SYLKAVSAAF VEIKTTKFTK KVQIDPYLED SLCHICSSQP GPFFCRDQVC FKYFCRSCWH WRHSMEGLRH HSPLMRNQKN RDSS |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol, 1mM DTT |
| Concentration | 0.5 mg/ml (determined by Bradford assay) |
| Purity | > 85% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
| References |
Sasayama T., et al. (2005) Genes Cells. 10:627-638 Wilczynska A., et al. (2005) J. Cell Sci. 118:981-992 |
| Supplier | ARP |
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