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|Product Name||CRYAB (Crystallin alpha B), Human, Recombinant|
|Background||Alpha crystallins are composed of two gene products ; alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein(sHSP also known as the HSP20). They act as molecular chaperones and hold them in in large soluble aggregates. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional function of alpha-crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-B is expressed widely in many tissues and organs and occurs in many neurological diseases.|
|Synonyms||CRYAB, CRYA2, CRYAB (Crystallin alpha B), Rosenthal fiber component, Heat shock protein beta-5, HspB5, Renal carcinoma antigen NY-REN-27, Alpha crystallin B chain, AACRYA, Alpha(B) crystallin, Crystallin alpha polypeptide 2, CTPP 2, CTPP2, Heat shock 20 kD like protein, Heat shock protein beta 5, NY REN 27 antigen, Renal carcinoma antigen NY REN 27,|
|Amino Acid Sequence||MDIAIHHPWI RRPFFPFHSP SRLFDQFFGE HLLESDLFPT STSLSPFYLR PPSFLRAPSW FDTGLSEMRL EKDRFSVNLD VKHFSPEELK VKVLGDVIEV HGKHEERQDE HGFISREFHR KYRIPADVDP LTITSSLSSD GVLTVNGPRK QVSGPERTIP ITREEKPAVT AAPKK|
|Molecular Weight||24.4 kDa (221 aa), confirmed by MALDI-TOF.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM MgCl2, 10% glycerol|
|Purity||> 95% by SDS-PAGE|
|NCBI Accession #||NP_001876.1|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Hasan, A., et al.(2002) Biochemistry 41(52) 15876-15882
Kamradt,M.C.., et al(2002) J. Biol.Chem. 277(41) 38731-38736
Reddy, G.B., et al(2002) FEBS lett. 522(1-3) 59-64
Ito, H., et al(2002) J.Biochem.131(4) 593-603
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