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|Product Name||DCAF7, 19-295aa, Human|
|Background||DCAF7, also known as DDB1-and CUL4-associated factor, involved in craniofacial development. This protein acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches. This protein associates with DIAPH1 and controls GLI1 transcriptional activity. This protein could be involved in normal and disease skin development. Recombinant human DCAF7 protein, fused to His-tag at N-terminus, was expressed in E.coli and denatured using detergent during conventional chromatography purification process.|
|Synonyms||DDB1-and CUL4-associated factor 7, AN11, HAN11, SWAN-1, WDR68|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MVYAMNWSVR PDKRFRLALG SFVEEYNNKV QLVGLDEESS EFICRNTFDH PYPTTKLMWI PDTKGVYPDL LATSGDYLRV WRVGETETRL ECLLNNNKNS DFCAPLTSFD WNEVDPYLLG TSSIDTTCTI WGLETGQVLG RVNLVSGHVK TQLIAHDKEV YDIAFSRAGG GRDMFASVGA DGSVRMFDLR HLEHSTIIYE DPQHHPLLRL CWNKQDPNYL ATMAMDGMEV VILDVRVPCT PVARLNNHRA CVNGIAWAPH SSCHICTAAD DHQALIWD|
|Molecular Weight||28.2 kDa (267aa), confirmed by MALDI-TOF|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 2mM DTT.|
|Purity||> 90% by SDS-PAGE|
|NCBI Accession #||NP_005819|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Morita K., et al. (2006) J. Dermatol. Sci. 44:11-20
Jin J., et al. (2006) Mol. Cell. 23:709-721
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