DUSP26, 1-211aa, Human

Category: Proteins
Catalog
01-P2324
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Product Name DUSP26, 1-211aa, Human
Description DUSP26 inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. This protein inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. DUSP26 can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). Recombinant human DUSP26 protein, fused to His-tag at N-terminus, was expressed in E.coli .
Synonyms Dual specificity protein phosphatase 26, Dual specificity phosphatase 26 (putative), DUSP24, LDP-4, MKP8, NATA1, SKRP3
Host E.coli
Molecular Weight 34.4 kDa (307aa) confirmed by MALDI-TOF
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MGSMCPGNWL WASMTFMARF SRSSSRSPVR TRGTLEEMPT VQHPFLNVFE LERLLYTGKT ACNHADEVWP GLYLGDQDMA NNRRELRRLG ITHVLNASHS RWRGTPEAYE GLGIRYLGVE AHDSPAFDMS IHFQTAADFI HRALSQPGGK ILVHCAVGVS RSATLVLAYL MLYHHLTLVE AIKKVKDHRG IIPNRGFLRQ LLALDRRLRQ GLEA
Tag His-tag
Reactivity Human
Applications SDS-PAGE
Form Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 40% glycerol, 2mM DTT
Concentration 0.25 mg/ml (determined by Bradford assay)
Purity > 85% by SDS-PAGE
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
References Vasudevan S.A.. et al. (2005). Biochem. Biophys. Res. Commun. 330:511-518
Yu W., et al. (2007). Oncogene 26:1178-1187
Supplier ARP

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