FADD, 1-208aa, Human

Category: Proteins
Catalog
01-2355-HT
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Product Name FADD, 1-208aa, Human
Description FADD (Fas-associated protein with death domain) is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. This protein is implicated in survival/proliferation and cell cycle progression. FADD functions are also regulated via cellular sublocalization, protein phosphorylation, and inhibitory molecules. Recombinant FADD protein was expressed in E.coli and purified by using conventional chromatography techniques.
Synonyms GIG3, MORT1, Fas-associated via death domain, Fas-associated death domain FADD protein, Fas associated via death domain, Fas (TNFRSF6) associated via death domain, Fas associating death domain containing protein, Fas associating protein with death domain, Fas TNFRSF6 associated via death domain, Fas associating protein, GIG 3, MGC8528, Growth inhibiting gene 3 protein, MORT 1, H sapiens mRNA for mediator of receptor induced toxicity, Mediator of receptor induced toxicity,
Host E.coli
Molecular Weight 11.5 kDa (100aa), confirmed by MALDI-TOF.
Amino Acid Sequence MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMDPF LVLLHSVSSS LSSSELTELK FLCLGRVGKR KLERVQSGLD LFSMLLEQND LEPGHTELLR ELLASLRRHD LLRRVDDFEA GAAAGAAPGE EDLCAAFNVI CDNVGKDWRR LARQLKVSDT KIDSIEDRYP RNLTERVRES LRIWKNTEKE NATVAHLVGA LRSCQMNLVA DLVQEVQQAR DLQNRSGAMS PMSWNSDAST SEAS
Reactivity Human
Applications SDS-PAGE
Form Liquid, in 20mM Tris-HCl buffer (pH7.5) containing 1mM DTT, 10% glycerol, 1mM EDTA
Concentration 1 mg/ml (determined by Bradford assay)
Purity > 95% by SDS-PAGE
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
References Eberstadt M., et al. (1998) Nature. 392(6679):941-5.
Matsuyoshi S., et al. (2006) Br J Cancer. 94(4):532-9.
Supplier ARP

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