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|Product Name||FCGR3A, 18-208aa, Human|
|Background||Low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A), also known as CD16A. This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other antibody-dependent responses. FCGR3A requires association of the gamma subunit of Fc epsilon RI or the zeta subunit of the TCR-CD3 complex for cell surface expression. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Recombinant human FCGR3A protein, fused to His-tag at N-terminus, was expressed in E.coli.|
|Synonyms||Low affinity immunoglobulin gamma Fc region receptor III-A, CD16, CD16A, FCG3, FCGR3, FCGRIII, FCR-10, FCRIII, FCRIIIA, IGFR3|
|Amino Acid Sequence||MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMRT EDLPKAVVFL EPQWYRVLEK DSVTLKCQGA YSPEDNSTQW FHNESLISSQ ASSYFIDAAT VDDSGEYRCQ TNLSTLSDPV QLEVHIGWLL LQAPRWVFKE EDPIHLRCHS WKNTALHKVT YLQNGKGRKY FHHNSDFYIP KATLKDSGSY FCRGLFGSKN VSSETVNITI TQGLAVSTIS SFFPPGYQ|
|Molecular Weight||26.9kDa (251aa), confirmed by MALDI-TOF
(Molecular weight on SDS-PAGE will appear higher)
|Concentration||0.5 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol,1mM DTT|
|Purity||> 90% by SDS-PAGE|
|NCBI Accession #||NP_001121065|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Huizinga T W., et al. (1988) Nature. 333:667-669.
Nagarajan S., et al. (1995) J Biol Chem. 270:25762-25770.
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