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|Product Name||FSBP, 1-299aa, Human|
|Background||Fibrinogen silencer-binding protein, also known as FSBP, is interacts with X11alpha. X11alpha/FSBP complex signals to the nucleus to repress glycogen synthase kinase-3beta promoter activity. X11alpha is a neuronal adaptor protein that interacts with the amyloid precursor protein (APP) through a centrally located phosphotyrosine binding domain to inhibit the production of Abeta peptide that is deposited in Alzheimer's disease brains. Recombinant human FSBP protein, fused to His-tag at N-terminus, was expressed in E.coli.|
|Synonyms||Fibrinogen silencer-binding protein, Fibrinogen silencer binding protein|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MGSMVGKARS SNFTLSEKLD LLKLVKPYVK ILEEHTNKHS VIVEKNRCWD IIAVNYNAIG VDRPPRTAQG LRTLYKRLKE YAKQELLQQK ETQSDFKSNI SEPTKKVMEM IPQISSFCLV RDRNHIQSAN LDEEAQAGTS SLQVMLDHHP VAITVEVKQE EDIKPPPPLV LNSQQSDTLE QREEHELVHV MERSLSPSLS SVDMRMTSSP SSIPRRDDFF RHESGEHFRS LLGYDPQILQ MLKEEHQIIL ENQKNFGLYV QEKRDGLKRR QQLEEELLRA KIEVEKLKAI RLRHDLPEYN SL|
|Molecular Weight||19.7kDa (171aa), confirmed by MALDI-TOF|
|Concentration||0.25 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT 30% glycerol, 0.15M NaCl|
|Purity||> 85% by SDS-PAGE|
|NCBI Accession #||NP_001243070|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Lau KF., et al. (2010) Neuroreport. 21(11):761-6|
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