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|Product Name||GADD45G, 1-159aa, Human, Recombinant|
|Background||GADD45G is a member of GADD45 family (GADD45alpha, beta, and gamma) that are nuclear proteins to interact with various proteins implicated in stress responses and cell-cycle-related proteins. The function of GADD45 proteins is involved in growth-regulatory mechanisms and apoptosis. GADD45G protein responds to environmental stresses by mediating activation of p38/JNK pathway via MTK1/MEKK4 kinase and its transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. Recombinant GADD45G protein was expressed in E.coli and purified by using conventional chromatography techniques.|
|Synonyms||CR6, DDIT2, Growth arrest and DNA-damage-inducible gamma, Growth arrest and DNA-damage-inducible gamma, Cytokine responsive protein CR6, GADD45G, Growth arrest and DNA damage inducible gamma, GRP17|
|Amino Acid Sequence||MTLEELVACD NAAQKMQTVT AAVEELLVAA QRQDRLTVGV YESAKLMNVD PDSVVLCLLA IDEEEEDDIA LQIHFTLIQS FCCDNDINIV RVSGMQRLAQ LLGEPAETQG TTEARDLHCL LVTNPHTDAW KSHGLVEVAS YCEESRGNNQ WVPYISLQER|
|Molecular Weight||21kDa (183aa), confirmed by MALDI-TOF.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris pH 7.5, 1mM DTT, 10% glycerol|
|Purity||> 95% by SDS-PAGE|
|NCBI Accession #||NP_006696|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Takekawa M., et al. (1998) Cell 95(4), 521-30
Zerbini LF., et al. (2004) PNAS 101(37), 13618-23
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