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|Product Name||GAGA-POZ domain (1-130aa), Drosophila melanogaster Recombinant|
|Background||The GAGA factor is a sequence-specific DNA-binding protein, which participates in the regulation of the expression of a variety of different classes of genes in Drosophila such as many developmentally regulated genes, stress induced genes, and cell cycle regulated genes, as well as housekeeping genes. GAGA contains a C-terminal glutamine-rich domain and a highly conserved N-terminal POZ domain which reported to be involved in self-oligomerization in a number of other POZ domain containing proteins. In case of GAGA protein, the N-terminal POZ domain mediates the formation of oligomers both in vitro and in vivo. GAGA-POZ domain was overexpressed in E.coli and purified by using conventional chromatography techniques|
|Synonyms||Trl, Adf-2, GAGA, Nc70F, TFGAGA, GAGA-POZ domain, Trithorax-like protein, GAGA factor, GAF, Adh transcription factor 2, Neural conserved at 70F, Transcription factor GAGA, Trithorax-like isoform A, Trithorax like protein|
|Amino Acid Sequence||MSLPMNSLYS LTWGDYGTSL VSAIQLLRCH GDLVDCTLAA GGRSFPAHKI VLCAASPFLL DLLKNTPCKH PVVMLAGVNA NDLEALLEFV YRGEVSVDHA QLPSLLQAAQ CLNIQGLAPQ TVTKDDYTTH|
|Molecular Weight||48.6 kDa (429 aa)|
|Concentration||0.5 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20 mM Tris-HCl buffer (pH 7.0) containing 100mM NaCl, 0.5mM DTT, 0.1mM EDTA, 0.1mM PMSF, 1mM MgCl2, 40% glycerol|
|Purity||> 95% by SDS-PAGE|
|NCBI Accession #||NP_996080|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Kosoy A., et al. (2002) J Biol.Chem. 277(44), 42280-8.
Espinas ML., et al. (1999) J Biol. Chem. 274(23),16461-9.
Farkas G., et al. (1994) Nature 371, 806-808.
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