HLA-DRB1, 30-227aa Human

Catalog
01-P2585
$0.00
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Proteins, Recombinant
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Product Name HLA-DRB1, 30-227aa Human
Background HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Recombinant human HLA-DRB1 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Synonyms Major histocompatibility complex, class II, DR beta 1, DRB1, HLA DRB1, HLA-DR1B, HLA-DRB1
Species Human
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MGDTRPRFLW QPKRECHFFN GTERVRFLDR YFYNQEESVR FDSDVGEFRA VTELGRPDAE YWNSQKDILE QARAAVDTYC RHNYGVVESF TVQRRVQPKV TVYPSKTQPL QHHNLLVCSV SGFYPGSIEV RWFLNGQEEK AGMVSTGLIQ NGDWTFQTLV MLETVPRSGE VYTCQVEHPS VTSPLTVEWR ARSESAQSK
Molecular Weight 50.5 kDa(455aa)
Concentration 0.5mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.4M Urea
Purity > 85% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_002115
Host E.coli
Tag His-tag
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Menendez-Benito V., et al. (2007) Immunity. 26:1-3
De Gassart A., et al. (2008) Proc. Natl. Acad. Sci. U.S.A. 105:3491-3496

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