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|Product Name||HMGB3, 1-180aa, Human|
|Background||HMGB3 belongs to the high mobility group (HMG) protein superfamily. Like HMG1 (MIM 163905) and HMG2 (MIM 163906), HMGB3 contains DNA-binding HMG box domains and is classified into the HMG box subfamily. Members of the HMG box subfamily are thought to play a fundamental role in DNA replication, nucleosome assembly and transcription. Recombinant human HMGB3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Synonyms||High mobility group protein B3, HMG-2a, HMG-4, HMG2A, HMG4|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MGSMAKGDPK KPKGKMSAYA FFVQTCREEH KKKNPEVPVN FAEFSKKCSE RWKTMSGKEK SKFDEMAKAD KVRYDREMKD YGPAKGGKKK KDPNAPKRPP SGFFLFCSEF RPKIKSTNPG ISIGDVAKKL GEMWNNLNDS EKQPYITKAA KLKEKYEKDV ADYKSKGKFD GAKGPAKVAR KKV|
|Molecular Weight||15.4kDa (136aa), confirmed by MALDI-TOF|
|Concentration||0.25mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 20% glycerol, 1mM DTT|
|Purity||> 85% by SDS-PAGE|
|NCBI Accession #||NP_005333|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Nemeth,M.J., et al. (2006) Proc. Natl. Acad. Sci. U.S.A. 103 (37), 13783-13788
Ross,M.T., et al. (2005) Nature 434 (7031), 325-337
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