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|Product Name||Homer 1, 1- 354aa, Human, Recombinant|
|Background||Homer 1(Homer protein homolog 1) belongs to Homer family of proteins that regulate signal transduction through, and the trafficking of, glutamate receptors, as well as maintain and regulate extracellular glutamate levels in corticolimbic brain regions. The Homer 1 is enriched at excitatory synapses and binds group 1 metabotropic glutamate receptors (mGluRs). Recombinant Homer 1 protein was expressed in E.coli and purified by using conventional chromatography techniques.|
|Synonyms||HOMER, HOMER1A, HOMER1B, HOMER1C, SYN47, Homer protein homolog 1, Homer 1, Homer protein homolog 1 HOMER 1A, HOMER 1B, HOMER 1C, Homer, neuronal immediate early gene, 1, HOMER1, Ves 1,|
|Amino Acid Sequence||MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMGE QPIFSTRAHV FQIDPNTKKN WVPTSKHAVT VSYFYDSTRN VYRIISLDGS KAIINSTITP NMTFTKTSQK FGQWADSRAN TVYGLGFSSE HHLSKFAEKF QEFKEAARLA KEKSQEKMEL TSTPSQESAG GDLQSPLTPE SINGTDDERT PDVTQNSEPR AEPTQNALPF SHSSAISKHW EAELATLKGN NAKLTAALLE STANVKQWKQ QLAAYQEEAE RLHKRVTELE CVSSQANAVH THKTELNQTI QELEETLKLK EEEIERLKQE IDNARELQEQ RDSLTQKLQE VEIRNKDLEG QLSDLEQRLE KSQNEQEAFR NNLKTLLEIL DGKIFELTEL RDNLAKLLEC S|
|Molecular Weight||23.8 kDa (222aa), confirmed by MALDI-TOF.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20 mM Tris-HCl buffer (pH 8.0) containing 100mM NaCl, 20% glycerol|
|Purity||> 90% by SDS-PAGE|
|NCBI Accession #||NP_004263|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Szumlinski KK., et al. (2008) Biochem Pharmacol. 75(1):112-133.
Roche KW., et al. (1999) J Biol Chem. 274(36):25953-7.
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