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|Product Name||HPGD, 1-266aa, Human|
|Background||HPGD, also known as 15-PGDH, is the fundamental enzyme of prostaglandin degradation. This protein strongly reduces the biologic activity of these molecules by catalyzing the oxidation of the 15-hydroxyl group of prostaglandins to a keto group. HPGD is implicated in many physiologic and cellular processes, such as inflammation. Recombinant human HPGD protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques|
|Synonyms||15-hydroxyprostaglandin dehydrogenase [NAD+], 15-PGDH, PGDH, PGDH1, SDR36C1, Prostaglandin dehydrogenase 1|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MHVNGKVALV TGAAQGIGRA FAEALLLKGA KVALVDWNLE AGVQCKAALD EQFEPQKTLF IQCDVADQQQ LRDTFRKVVD HFGRLDILVN NAGVNNEKNW EKTLQINLVS VISGTYLGLD YMSKQNGGEG GIIINMSSLA GLMPVAQQPV YCASKHGIVG FTRSAALAAN LMNSGVRLNA ICPGFVNTAI LESIEKEENM GQYIEYKDHI KDMIKYYGIL DPPLIANGLI TLIEDDALNG AIMKITTSKG IHFQDYDTTP FQAKTQ|
|Molecular Weight||59.2 kDa (549aa), confirmed by MALDI-TOF|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20 mM Tris-HCl buffer (pH8.0) containing 0.2M NaCl, 1mM DTT, 10% glycerol|
|Purity||> 95% by SDS-PAGE|
|NCBI Accession #||NP_000851|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Han X., et al. (1995) Equine Vet. J. 27: 334-339.
Van Meir C.A., et al. (1996) Placenta 17: 291-297.
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