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|Product Name||HSPBP1, 1-362aa, Human|
|Background||Hsp70-binding protein 1, also known as HSPBP1, belongs to a family of eukaryotic proteins identified as nucleotide exchange factors for HSP 70, which exhibit varying degrees of compartment and species specificity. It is localized primarily in cytoplasm and nucleus but is also found extracellularly. HspBP1 binds to HSP 70, inhibits its activity and promotes dissociation of nucleotides from the HSP 70 ATPase domain. It is mainly expressed in heart and skeletal muscle. Recombinant human HSPBP1, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Synonyms||HSPBP, FES, Hsp70-binding protein 1 500019G21Rik, FES1, Heat shock protein 70 binding protein, Heat shock protein 70 interacting protein, Heat shock protein binding protein 1, Heat-shock 70-KD protein-binding protein 1, Hsp 70 binding protein, Hsp 70 interacting protein, Hsp70 binding protein 1, Hsp70 binding protein 2, Hsp70 interacting protein 1, Hsp70 interacting protein 2, HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1, HSPA-binding protein 1, HspBP1, HspBP2,|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MSDEGSRGSR LPLALPPASQ GCSSGGGGGG GGGSSAGGSG NSRPPRNLQG LLQMAITAGS EEPDPPPEPM SEERRQWLQE AMSAAFRGQR EEVEQMKSCL RVLSQPMPPT AGEAEQAADQ QEREGALELL ADLCENMDNA ADFCQLSGMH LLVGRYLEAG AAGLRWRAAQ LIGTCSQNVA AIQEQVLGLG ALRKLLRLLD RDACDTVRVK ALFAISCLVR EQEAGLLQFL RLDGFSVLMR AMQQQVQKLK VKSAFLLQNL LVGHPEHKGT LCSMGMVQQL VALVRTEHSP FHEHVLGALC SLVTDFPQGV RECREPELGL EELLRHRCQL LQQHEEYQEE LEFCEKLLQT CFSSPADDSM DR|
|Molecular Weight||12.9 kDa (119aa), confirmed by MALDI-TOF|
|Concentration||0.5 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT.|
|Purity||> 95% by SDS-PAGE|
|NCBI Accession #||AAH01236|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Ewdonin A., et al. (2009) Biol Cell. 101(6):351-60.
Souza AP., et al. (2009) Cell Stress Chaperones. 14(3): 301-10.
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