IPP-POZ domain (1-157aa), Human Recombinant

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01-2227
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Proteins, Recombinant
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Product Name IPP-POZ domain (1-157aa), Human Recombinant
Background Intracisternal A particle-promoted polypeptide(IPP) is a 66kDa protein(584 amino acids), which contains an N-terminal POZ protein-protein interaction domain and a C-terminla kelch repeat domain consisting of six tandem arranged repeats. The POZ domain(also called BTB domain) is present near the N-terminus of a fraction of zinc finger proteins and in protein that contain the pfam01344 motif such as kelch and pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-coR and SMRT. IPP-POZ domain(1-157aa) was overexpressed in E.coli and purified by using conventional chromatography techniques
Synonyms IPP, KLHL27, IPP-POZ domain, MIPP protein, Kelch-like protein 27, Actin-binding protein IPP, Intracisternal A particle-promoted polypeptide isoform 1, Protein phosphatase inhibitor 1, Actin binding protein IPP, I1, Intracisternal A particle promoted polypeptide, IPP POZ, Kelch like protein 27, Protein phosphatase 1 regulatory subunit 1A
Species Human
Amino Acid Sequence MANEDCPKAA DSPFSSDKHA QLILAQINKM RNGQHFCDVQ LQVGQESFKA HRLVLAASSP YFAALFTGGM KESSKDVVPI LGIEAGIFQI LLDFIYTGIV NIGVNNVQEL IIAADMLQLT EVVHLCCEFL KGQIDPLNCI GIFQFSEQIA CHDLLEF
Molecular Weight 28 kDa (261 aa), confirmed by MALDI-TOF.
Concentration 1 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris pH 7.5, 2mM EDTA, 20% glycerol
Purity > 95% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_005888
Host E.coli
Tag His-tag
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Kim IF., et al. (1999) Gene 228(1-2), 73-83.
Chang-Yeh, A., et al. (1993) Genomics. 15(1), 239-241.

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