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|Product Name||KIR2DL1 (p58 KIR, CD158), Human, Recombinant, Recombinant|
|Background||An inhibitory Keller Cell Ig-like Receptor(KIR, previously called p58 KIR, p58.1, cl-42, NKAT1, or KIR-K6), which recognizes class I MHC molecules(HLA-Cw2, -Cw4, -Cw5, and Cw6). The protein coding region of the extracellular domain of KIR2DL1(amino acids 1-202) was cloned into an E. coli expression vector. The extracellular domain of KIR2DL1 was overexpressed as insoluble protein aggregates(inclusion bodies). The recombinant KIR2DL1 protein was purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a redox buffer.|
|Synonyms||KIR2DL1, CD158A, NKAT1, KIR2DL1 (p58 KIR, CD158), MHC class I NK cell receptor, Natural killer-associated transcript 1, NKAT-1, p58 natural killer cell receptor clones CL-42/47.11, p58 NK receptor, p58.1 MHC class-I-specific NK receptor, Killer cell immunoglobulin-like receptor 2DL1, Killer cell immunoglobulin-like receptor 2DL1 Killer cell immunoglobulin like receptor 2DL1, MHC class I NK cell receptor, Natural killer associated transcript 1, NKAT 1, p58 NK receptor, p58.1 MHC class I specific NK receptor|
|Amino Acid Sequence||MEGVHRKPSL LAHPGRLVKS EETVILQCWS DVMFEHFLLH REGMFNDTLR LIGEHHDGVS KANFSISRMT QDLAGTYRCY GSVTHSPYQV SAPSDPLDIV IIGLYEKPSL SAQLGPTVLA GENVTLSCSS RSSYDMYHLS REGEAHERRL PAGPKVNGTF QADFPLGPAT HGGTYRCFGS FHDSPYEWSK SSDPLLVSVT GN|
|Molecular Weight||20kDa (179aa), confirmed by MALDI-TOF.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 50mM Tris pH 8.0, 0.1mM PMSF, 1mM EDTA, 1mM DTT, 10% glycerol.|
|Purity||> 95% by SDS-PAGE|
|NCBI Accession #||NP_055033|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Steffens, U. et al. (1998) Tissue Antigens 51, 398-413.
Wagtmann, N.R., et al. (1995) Immunity 2, 439-449.
Colonna, M. et al. (1995) Science 269, 405-408;
Kim, J. et al. (1997) J. Immunol. 159, 3875-3882.
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