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|Product Name||LDHA, 1-332aa, Human|
|Background||LDHA, also known as L-lactate dehydrogenase A chain, is an enzyme that catalyzes the conversion of L-lactate and NAD+ to pyruvate and NADH in the final step of anaerobic glycolysis. This protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in LDHA have been linked to exertional myoglobinuria. Recombinant LDHA protein was expressed in E.coli and purified by using conventional chromatography techniques.|
|Synonyms||GSD11, LDH1, LDHM, PIG19, L-lactate dehydrogenase A chain Cell proliferation-inducing gene 19 protein, LDH muscle subunit, M LDH, L lactate dehydrogenase A chain, l7R2, Lactate dehydrogenase 1, A chain, Lactate dehydrogenase A, Lactate dehydrogenase A4, Lactate dehydrogenase M, LDH muscle subunit, OTTMUSP00000017774, Proliferation-inducing gene 19, Renal carcinoma antigen NY-REN-59.|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MATLKDQLIY NLLKEEQTPQ NKITVVGVGA VGMACAISIL MKDLADELAL VDVIEDKLKG EMMDLQHGSL FLRTPKIVSG KDYNVTANSK LVIITAGARQ QEGESRLNLV QRNVNIFKFI IPNVVKYSPN CKLLIVSNPV DILTYVAWKI SGFPKNRVIG SGCNLDSARF RYLMGERLGV HPLSCHGWVL GEHGDSSVPV WSGMNVAGVS LKTLHPDLGT DKDKEQWKEV HKQVVESAYE VIKLKGYTSW AIGLSVADLA ESIMKNLRRV HPVSTMIKGL YGIKDDVFLS VPCILGQNGI SDLVKVTLTS EEEARLKKSA DTLWGIQKEL QF|
|Molecular Weight||19.6 kDa (180aa), confirmed by MALDI-TOF.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20 mM Tris-HCl buffer (pH8.0) containing 1mM DTT, 10% glycerol|
|Purity||> 95% by SDS-PAGE|
|NCBI Accession #||NP_005557|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Gosti F, et al. (1987) Proc. Natl. Acad. Sci. U.S.A. 84(4):1000-4
Chung FZ, et al. (1985) Biochem. J. 231(3):537-41.
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