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|Product Name||LDOC1L, 1-239aa, Human|
|Background||Leucine zipper, down-regulated in cancer 1-like, also known as LDOC1L, belongs to the LDOC1 family. LDOC1 is a nuclear protein that contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is downregulated in some cancer cell lines. LDOC1L is thought to regulate the transcriptional response mediated by the nuclear factor kB (NFkB). Recombinant human LDOC1L protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Synonyms||Protein LDOC1L, dJ1033E15.2, Mar6, Mart6|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MGSHMVQPQT SKAESPALAA SPNAQMDDVI DTLTSLRLTN SALRREASTL RAEKANLTNM LESVMAELTL LRTRARIPGA LQITPPISSI TSNGTRPMTT PPTSLPEPFS GDPGRLAGFL MQMDRFMIFQ ASRFPGEAER VAFLVSRLTG EAEKWAIPHM QPDSPLRNNY QGFLAELRRT YKSPLRHARR AQIRKTSASN RAVRERQMLC RQLASAGTGP CPVHPASNGT SPAPALPARA RNL|
|Molecular Weight||61.9 kDa (547aa)|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol|
|Purity||> 90% by SDS-PAGE|
|NCBI Accession #||NP_115663|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Nagasaki K., et al. (1999) Cancer Lett. 140: 227-234
Nagasaki K., et al. (2003) J Cancer. 105: 454-458.
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