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|Product Name||Lin28, 42-209aa, Human|
|Background||Lin-28 acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. It is marker of undifferentiated human embryonic stem cells and has been used to enhance the efficiency of the formation of induced pluripotent stem (iPS) cells from human fibroblasts. It has also been shown to bind to the let-7 pre-miRNA and block production of the mature let-7 microRNA in mouse embryonic stem cells. Recombinant Lin28 protein was expressed in E.coli and purified by using conventional chromatography techniques.|
|Synonyms||CSDD1, FLJ12457, LIN-28, LIN28A, ZCCHC1, Zinc finger CCHC domain-containing protein 1 AL024421.Lin 28, Lin 28 homolog, Tex17, Lin28a, Lin 28 homolog (C, elegans), Lin 28 homolog A, RNA binding protein lin 28, Zinc finger CCHC domain containing protein 1.|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH RSMGICKWFN VRMGFGFLSM TARAGVALDP PVDVFVHQSK LHMEGFRSLK EGEAVEFTFK KSAKGLESIR VTGPGGVFCI GSERRPKGKS MQKRRSKGDR CYNCGGLDHH AKECKLPPQP KKCHFCQSIS HMVASCPLKA QQGPSAQGKP TYFREEEEEI HSPTLLPEAQ N|
|Molecular Weight||27.4 kDa (244aa), confirmed by MALDI-TOF.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol.|
|Purity||> 90% by SDS-PAGE|
|NCBI Accession #||NP_078950|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Moss E.G., et al. (2003) Dev. Biol. 258:432-442
Heo I., et al. (2009) Cell. 138:696-708.
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