M6PR, 27-185aa, Human

Catalog
01-P2675
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Proteins, Recombinant
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Product Name M6PR, 27-185aa, Human
Background M6PR is a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. This protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. Recombinant human M6PR protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques..
Synonyms Cation-dependent mannose-6-phosphate receptor isoform 1, CD-MPR, MPR 46, MPR-46, MPR46, SMPR
Species Human
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MGSTEEKTCD LVGEKGKESE KELALVKRLK PLFNKSFEST VGQGSDTYIY IFRVCREAGN HTSGAGLVQI
NKSNGKETVV GRLNETHIFN GSNWIMLIYK GGDEYDNHCG KEQRRAVVMI SCNRHTLADN FNPVSEERGK VQDCFYLFEM DSSLACSPEI
SH
Molecular Weight 23.2 kDa (199aa)
Concentration 1 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol
Purity > 85% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_002346
Host E.coli
Tag His-tag
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Prabakaran T, Nielsen R., et al. (2012) PLoS One. 2012;7(6):e39975.

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