MLF1IP, 147-418a, Human

Catalog
01-P2495
$0.00
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Proteins, Recombinant
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Product Name MLF1IP, 147-418a, Human
Background MLF1IP, as known as centromere, is a specialized chromatin domain, present throughout the cell cycle that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. It plays an important role in the correct PLK1 localization to the mitotic kinetochores. It is a scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. It also involved in transcriptional repression. Recombinant human MLF1IP protein, fused to His-tag at N-terminus, was expressed in E.coli.
Synonyms CENP50, CENPU, CENPU50, KLIP1, PBIP1
Species Human
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MGSTRRKVKS AEKISTQRHE VIRTTASSEL SEKPAESVTS KKTGPLSAQP SVEKENLAIE SQSKTQKKGK
ISHDKRKKSR SKAIGSDTSD IVHIWCPEGM KTSDIKELNI VLPEFEKTHL EHQQRIESKV CKAAIATFYV NVKEQFIKML KESQMLTNLK
RKNAKMISDI EKKRQRMIEV QDELLRLEPQ LKQLQTKYDE LKERKSSLRN AAYFLSNLKQ LYQDYSDVQA QEPNVKETYD SSSLPALLFK
ARTLLGAESH LRNINHQLEK LLDQG
Molecular Weight 47.2kDa (429aa) confirmed by MALDI-TOF
Concentration 0.5 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl (pH8.0) containing 20% glycerol,
0.15M NaCl, 1mM DTT
Purity > 80% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_078905
Host E.coli
Tag His-tag
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Foltz DR. et al. (2006) Nat Cell Biol. 8:458-469.

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