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|Product Name||Mouse PRMT1 isoform2, 1-353aa, Mouse, Recombinant|
|Background||Protein arginine N-methyltransferase 1(PRMT1) is a type I methyltransferase that transfers a methyl group from S-adenosylmethionine to guanidino nitrogens of arginine residues to form monomethylarginine and asymmetric dimethylarginine. Functions of type I arginine methylation in proteins may include regulation of transcription, modulation of the affinity of nucleic acid-binding proteins, regulation of interferon signaling pathways, and targeting of nuclear proteins. Mouse PRMT1(AAF37293) shares 99.9% sequence identity with the human proteins(NP_938074). Recombinant mouse PRMT1, fused to His-MBP tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Synonyms||Mrmt1, Hrmt112, AW214366, Protein arginine N-methytransferase 1, PRMT1 isoform2, PRMT1, Protein arginine N-methyltransferase 1 ANM 1, HCP 1, HMT1 hnRNP methyltransferase, Heterogeneous nuclear ribonucleoproteins methyltransferase like 2, HMT2, HRMT1 L2, HRMT1L 2, Heterogeneous nuclear ribonucleoproteins methyltransferase like2, HMT 2, HMT1 (hnRNP methyltransferase S, cerevisiae) like 2, HMT1 hnRNP methyltransferase like 2, HMT1 hnRNP methyltransferase like 2 (S, cerevisiae), Human mRNA for suppressor for yeast mutant, Human mRNA for suppressor for yeast mutant complete cds, Interferon receptor 1 bound protein 4, Interferon receptor 1 bound protein4, Interferon receptor 1bound protein 4, IR1 B4, IR1B 4, Mrmt 1, Mrmt1, PRMT 1, R1B4, S, cerevisiae like 2, Protein arginine N methyltransferase 1, Protein arginine N methyltransferase1,|
|Amino Acid Sequence||MHHHHHHMKI EEGKLVIWIN GDKGYNGLAE VGKKFEKDTG IKVTVEHPDK LEEKFPQVAA TGDGPDIIFW AHDRFGGYAQ SGLLAEITPD KAFQDKLYPF TWDAVRYNGK LIAYPIAVEA LSLIYNKDLL PNPPKTWEEI PALDKELKAK GKSALMFNLQ EPYFTWPLIA ADGGYAFKYE NGKYDIKDVG VDNAGAKAGL TFLVDLIKNK HMNADTDYSI AEAAFNKGET AMTINGPWAW SNIDTSKVNY GVTVLPTFKG QPSKPFVGVL SAGINAASPN KELAKEFLEN YLLTDEGLEA VNKDKPLGAV ALKSYEEELA KDPRIAATME NAQKGEIMPN IPQMSAFWYA VRTAVINAAS GRQTVDEALK DAQTNSSSNN NNNNNNNNLG IEGRGSHMAA AEAANCIMEV SCGQAESSEK PNAEDMTSKD YYFDSYAHFG IHEEMLKDEV RTLTYRNSMF HNRHLFKDKV VLDVGSGTGI LCMFAAKAGA RKVIGIECSS ISDYAVKIVK ANKLDHVVTI IKGKVEEVEL PVEKVDIIIS EWMGYCLFYE SMLNTVLHAR DKWLAPDGLI FPDRATLYVT AIEDRQYKDY KIHWWENVYG FDMSCIKDVA IKEPLVDVVD PKQLVTNACL IKEVDIYTVK VEDLTFTSPF CLQVKRNDYV HALVAYFNIE FTRCHKRTGF STSPESPYTH WKQTVFYMED YLTVKTGEEI FGTIGMRPNA KNNRDLDFTI DLDFKGQLCE LSCSTDYRMR|
|Molecular Weight||27 kDa (250 aa), confirmed by MALDI-TOF.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 25mM Tris pH 7.5, 1mM DTT, 1mM EDTA, 2mM beta-mercaptoethanol, 20% glycerol|
|Purity||> 90% by SDS-PAGE|
|NCBI Accession #||AAF37293|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Herrmann F., et al. (2005). J Biol Chem. 280(45):38005-10.
Abramovich C., et al. (1997). EMBO J. 16(2):260-6.
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