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|Product Name||MZB1, 1-97aa, Human|
|Background||Marginal zone B- and B1-cell-specific protein, also known as MZB1, acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. This protein may have a role in the onset of insulin resistance. Recombinant human MZB1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Synonyms||Marginal zone B- and B1-cell-specific protein, PACAP, MEDA7|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MGSMPAELWL TSYGVREVDQ VKRLTGPGLS EGPEPSISVM VTGGPWPTRL SRTCLHYLGE FGEDQIYEAH
QQGRGALEAL LCGGPQGACS EKVSATREEL
|Molecular Weight||19.9 kDa (177aa)|
|Concentration||1.0 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing
10% glycerol, 0.4M Urea
|Purity||> 90% by SDS-PAGE|
|NCBI Accession #||AAH09931|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Bonfoco E., et al. (2001) J. Biol. Chem. 276:29242-29250
Zhang H., et al. (2011) Diabetologia. 54:2368-2380
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