NDP, 25-133aa, Human

Catalog
01-P2290
$0.00
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Proteins, Recombinant
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More Information
Product Name NDP, 25-133aa, Human
Background Norrin precursor, also known as NDP, is a secreted regulatory protein. It activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. This protein plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. It may be involved in a pathway that regulates neural cell differentiation and proliferation. Recombinant human NDP protein, fused to His-tag at N-terminus, was expressed in E.coli.
Synonyms Norrin, EVR2, FEVR, ND
Species Human
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MGSKTDSSFI MDSDPRRCMR HHYVDSISHP LYKCSSKMVL LARCEGHCSQ ASRSEPLVSF STVLKQPFRS SCHCCRPQTS KLKALRLRCS GGMRLTATYR YILSCHCEEC NS
Molecular Weight 18.1 kDa (160aa)
Concentration 0.5mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M Urea
Purity > 80% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_000257
Host E.coli
Tag His-tag
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Luhmann U F., et al. (2005) Invest Pothalmol Vis Sci. 46:3372-3382.
Luhmann U F., et al. (2005) Genesis. 42:253-262

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