NDUFA5, 1-116aa, Human

Catalog
01-P1762
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Proteins, Recombinant
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Product Name NDUFA5, 1-116aa, Human
Background NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5, also known as NDUFA5, belongs to the complex I NDUFA5 subunit family. The human NDUFA5 gene codes for the B13 subunit of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. The high degree of conservation of NDUFA5 extending to plants and fungi indicates its functional significance in the enzyme complex. The protein localizes to the inner mitochondrial membrane as part of the 7 component-containing, water soluble 'iron-sulfur protein' (IP) fraction of complex I, although its specific role is unknown. It is assumed to undergo post-translational removal of the initiator methionine and N-acetylation of the next amino acid. Recombinant human NDUFA5 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques
Synonyms NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5, B13, CI-13kB, CI-13KD-B, NUFM, UQOR13
Species Human
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MGSMAGVLKK TTGLVGLAVC NTPHERLRIL YTKILDVLEE IPKNAAYRKY TEQITNEKLA MVKAEPDVKK LEDQLQGGQL EEVILQAEHE LNLARKMREW KLWEPLVEEP PADQWKWPI
Molecular Weight 28.4 kDa (256aa) confirmed by MALDI-TOF
Concentration 0.25 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol,1mM DTT
Purity > 90% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_004991
Host E.coli
Tag His-tag
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Murray J., et al. (2003) J. Biol. Chem. 278:13619-13622
Choudhary C., et al. (2009) Science. 325:834-840

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