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|Product Name||NME1, 1-152aa, Human, Recombinant|
|Background||Non-metastatic cells 1 (NME1), also known as NM23-H1, originally identified as a candidate metastasis suppressor gene. NME1 is expressed in different tumor types where their levels have been alternatively associated with reduced or increased metastatic potential. Reductions in NME1 expression have been significantly associated with aggressive behavior in melanoma, breast, colon, and gastric carcinomas. On the contrary, high levels of NME1 gene expression are noted in the advanced stage of thyroid carcinomas. Recombinant human NME1 was expressed in E.coli and purified by using conventional chromatography techniques.|
|Synonyms||Nucleoside diphosphate kinase A, NDP kinase A, AWD, GAAD, NB, NBS, NDPK-A, NM23, NM23-H1, Non-metastatic cells 1 AWD, drosophila, homolog of, NDPKA, NM23, NM23-M1, Granzyme A activated DNase, GZMA activated DNase, Metastasis inhibition factor nm23, NDK A, NDP Kinase A, NM23 long variant, included, Nonmetastatic protein 23, NME1-NME2 spliced read-through transcript, included, Non-metastatic cells 1, protein (NM23A) expressed in, Nonmetastatic cells 1, protein expressed in, NME1, Nucleoside diphosphate kinase A, Nonmetastatic protein 23, homolog 1, NM23H1B, included, Tumor metastatic process-associated protein.|
|Amino Acid Sequence||MANCERTFIA IKPDGVQRGL VGEIIKRFEQ KGFRLVGLKF MQASEDLLKE HYVDLKDRPF FAGLVKYMHS GPVVAMVWEG LNVVKTGRVM LGETNPADSK PGTIRGDFCI QVGRNIIHGS DSVESAEKEI GLWFHPEELV DYTSCAQNWI YE|
|Endotoxin Level||< 1.0 EU per 1 microgram of protein (determined by LAL method)|
|Molecular Weight||27.1 kDa (244aa), confirmed by MALDI-TOF.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH8.0) containing 20% Glycerol|
|Purity||> 95% by SDS-PAGE|
|NCBI Accession #||NP_000260|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Tee YT., et al. (2006) Taiwan J Obstet Gynecol. 45(2):107-13.
Negroni A., et al. (2000) Cell Death Differ. 7(9):843-50.
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