PCBD1, 1-104aa, Human

Proteins, Recombinant
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Product Name PCBD1, 1-104aa, Human
Background Pterin-4-alpha-carbinolamine dehydratase precursor, also known as PCBD1, is a component of the phenylalanine hydroxylase (PAH) system and participates in tetrahydrobiopterin biosynthesis. A deficiency of this enzyme leads to hyperphenylalaninemia. The enzyme regulates the homodimerization of the transcription factor hepatocyte nuclear factor 1 (HNF1). Recombinant human PCBD1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Synonyms Pterin-4-alpha-carbinolamine dehydratase, DCOH, PCBD, PCD, PHS
Species Human
Molecular Weight 33.7kDa (291aa), confirmed by MALDI-TOF
Concentration 1.0 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol
Purity > 95% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_000272
Host E.coli
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Schallreuter K U., et al. (2004) Biochem Biophys Res Commun. 315:502-508.
Hasse S., et al. (2005) Exp Dermatol. 14:182-187.

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