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|Product Name||PCSK1N, 34-260aa, Human|
|Background||Members of the subtilisin-like proprotein convertase family process latent precursor proteins into their biologically active products. PCSK1N functions as an inhibitor of prohormone convertase 1, which regulates the proteolytic cleavage of neuroendocrine peptide precursors. Recombinant human PCSK1N protein, fused to His-tag at N-terminus, was expressed in E.coli .|
|Synonyms||Proprotein convertase subtilisin/kexin type 1 inhibitor, PROSAAS; SAAS|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MGSMARPVKE PRGLSAASPP LAETGAPRRF RRSVPRGEAA GAVQELARAL AHLLEAERQE RARAEAQEAE
DQQARVLAQL LRVWGAPRNS DPALGLDDDP DAPAAQLARA LLRARLDPAA LAAQLVPAPV PAAALRPRPP VYDDGPAGPD AEEAGDETPD
VDPELLRYLL GRILAGSADS EGVAAPRRLR RAADHDVGSE LPPEGVLGAL LRVKRLETPA PQVPARRLLP P
|Molecular Weight||28.8kDa (279aa) confirmed by MALDI-TOF|
|Concentration||0.25 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl,
50% glycerol, 2mM DTT, 1mM EDTA
|Purity||>85 % by SDS-PAGE|
|NCBI Accession #||NP_037403|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Fricker L., McKinzie A.A.. et al. (2000). J. Neurosci. 20:639-648|
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