PDIA3, 25-505aa, Human

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01-1769-3
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Proteins, Recombinant
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Product Name PDIA3, 25-505aa, Human
Background PDIA3, also known as protein disulfide-isomerase A3, is a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. This protein has protein disulfide isomerase activity. PDIA3 is also part of the major histocompatibility complex (MHC) class I peptide-loading complex (TAP1), which is essential for formation of the final antigen conformation and export from the endoplasmic reticulum to the cell surface. Recombinant human PDIA3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Synonyms ER60, ERp57, ERp60, ERp61, GRP57, GRP58, HsT17083, P58, PI-PLC, Protein disulfide-isomerase A3 58 kDa glucose regulated protein, 58 kDa microsomal protein, Disulfide isomerase ER 60, ER p57, ERp 57, Glucose Regulated Protein 58 Kd, GRP 57, GRP 58, HsT17083, PDIA 3, PDIA3, Phospholipase C alpha, PI PLC, Protein disulfide isomerase A3, Protein disulfide isomerase family A member 3.
Species Human
Amino Acid Sequence MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMSDV LELTDDNFES RISDTGSAGL MLVEFFAPWC GHCKRLAPEY EAAATRLKGI VPLAKVDCTA NTNTCNKYGV SGYPTLKIFR DGEEAGAYDG PRTADGIVSH LKKQAGPASV PLRTEEEFKK FISDKDASIV GFFDDSFSEA HSEFLKAASN LRDNYRFAHT NVESLVNEYD DNGEGIILFR PSHLTNKFED KTVAYTEQKM TSGKIKKFIQ ENIFGICPHM TEDNKDLIQG KDLLIAYYDV DYEKNAKGSN YWRNRVMMVA KKFLDAGHKL NFAVASRKTF SHELSDFGLE STAGEIPVVA IRTAKGEKFV MQEEFSRDGK ALERFLQDYF DGNLKRYLKS EPIPESNDGP VKVVVAENFD EIVNNENKDV LIEFYAPWCG HCKNLEPKYK ELGEKLSKDP NIVIAKMDAT ANDVPSPYEV RGFPTIYFSP ANKKLNPKKY EGGRELSDFI SYLQREATNP PVIQEEKPKK KKKAQEDL
Molecular Weight 15.5 kDa (141aa), confirmed by MALDI-TOF.
Concentration 1 mg/ml (determined by BCA)
Form Liquid, in 20mM Tris buffer (pH 8.0) containing 10% glycerol, 1mM DTT.
Purity > 95% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_005304
Host E.coli
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Vigneron N., et al. (2009) Eur J Immunol. 39(9):2371-6.
Forster ML., et al. (2009) J Biol Chem. 284(19):13045-56.

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