| Product Name | PEBP1, 1-187aa, Human, Recombinant |
|---|---|
| Description | Phosphatidylethanolamine binding protein 1 (PEBP1), also known as Raf kinase inhibitor protein (RKIP), is a member of the phosphatidylethanolamine-binding protein family and a serine protease inhibitor which inhibits thrombin, neuropsin. PEBP1 plays a pivotal modulatory role in several protein kinase signaling cascades. Protein kinase C (PKC) phosphorylates PEBP1, resulting in release of Raf-1 and activation of MEK and ERK. Expressed in many tissues, PEBP1 is implicated in the regulation of such physiological processes as membrane biosynthesis, spermatogenesis, neural development, and metastasis suppression. Recombinant human PEBP1 was expressed in E.coli and purified by using conventional chromatography techniques. |
| Synonyms | HCNP, PBP, PEBP, Phosphatidylethanolamine binding protein 1 Hippocampal cholinergic neurostimulating peptide, Neuropolypeptide h3, HCNPpp, PEBP, PEBP 1, PEBP1, Phosphatidylethanolamine binding protein, Prostatic binding protein, R kip, Raf kinase inhibitory protein RKIP. |
| Host | E.coli |
| Molecular Weight | 33.3 kDa (295aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher) |
| Amino Acid Sequence | MPVDLSKWSG PLSLQEVDEQ PQHPLHVTYA GAAVDELGKV LTPTQVKNRP TSISWDGLDS GKLYTLVLTD PDAPSRKDPK YREWHHFLVV NMKGNDISSG TVLSDYVGSG PPKGTGLHRY VWLVYEQDRP LKCDEPILSN RSGDHRGKFK VASFRKKYEL RAPVAGTCYQ AEWDDYVPKL YEQLSGK |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol |
| Concentration | 1 mg/ml (determined by Bradford assay) |
| Purity | > 95% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
| References |
Keller ET., et al. (2004) Biochem Pharmacol. 68(6):1049-53. Park S., et al. (2005) Oncogene. 24(21):3535-40. |
| Supplier | ARP |
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