Phosphoserine phosphatase Human, Recombinant

Proteins, Recombinant
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Product Name Phosphoserine phosphatase Human, Recombinant
Background Human Phosphoserine phosphatase (hPSP) is an important enzyme in the phosphorylated pathway of serine biosynthesis, which contributes a major portion of the endogenous L-serine. Similar to known L-3-phosphoserine phosphatases, it catalyzed the Mg2+ General references: -dependent hydrolysis of L-phosphoserine and an exchange reaction between L-serine and L-phosphoserine. Recently, its complex structures reveal that the open-closed environmental change of the active site, generated by local rearrangement of the alpha-helical bundle domain, is important to substrate recognition and hydrolysis. Recombinant human hPSP was overexpressed in E. coli and purified by conventional chromatography.
Synonyms PSPH, Phosphoserine phosphatase Human, PSPase, PSP, EC, O-phosphoserine phosphohydrolase, L-3-phosphoserine phosphatase, Phosphoserine phosphatase, L 3 phosphoserine phosphatase, O phosphoserine phosphohydrolase, Phosphoserine phosphatase deficiency, included,
Species Human
Endotoxin Level < 1.0 EU per 1 microgram of protein (determined by LAL method)
Molecular Weight 84 kDa (750 aa)
Concentration 1 mg/ml (determined by Bradford assay)
Form Liquid, in 40mM Tris pH 8.0, 100mM NaCl, 4mM MgCl2, 2mM DTT, 40% glycerol
Purity > 95% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_004568
Host E.coli
Tag His-tag
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Moro-Furlani., AM., et al. (1980) Ann. Hum. Genet. 43, 323-333
Collet JF., et al. (1997) FEBS Lett. 408, 281-284
Kim HY, et al. (2002) J Biol Chem. 277, 46651-8.

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